November 2012
Fetal Heart Rate Predictors of Long QT Syndrome
Mitchell JL, Cunei BF, Etheridge SP, Horigome H, Weng HY, Benson DW.
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Shunt Reintervention and Time-Related Events After Norwood Operation: Impact of Shunt Strategy
Polimenakos AC, Sathanandam SK, Blair C, El Zein CF, Husayni TS, Ilbawi MN
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September 2012
Proximal sano anastomosis aneurysm due to degeneration of bovine pericardial patch
ElZein C, Subramanian S, Roberson D, Husayni T, Polimenakos A, Ilbawi M
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August 2012
Transesophageal Echocardiography in Critically Ill Acute Postoperative Infants: Comparison of AcuNav Intracardiac Echocardiographic and microTEE Miniaturized Transducers.
Ferns S, Komarlu R, Van Bergen A, Multani K, Cui VW, Roberson DA
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July 2012
Isolated Cataplexy in the Differential Diagnosis of Drop Attacks: A Case of Successful Clinical Diagnosis and Treatment
Egel, RT, Lee A, Bump, T, Javois, A
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December 2011
Post-Cardiotomy Extracorporeal Cardiopulmonary Resuscitation in Neonates with Complex Single Ventricle: Analysis of Outcomes
Polimenakos AC, Wojtyla P, Smith PJ, Rizzo V, Nater M, El Zein CF, Ilbawi MN
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October 2011
Hypoplastic Left Heart Syndrome and Aortic Atresia-Mitral Stenosis Variant: Role of Myocardial Protection Strategy and Impact of Ventriculo-Coronary Connections After Stage I Palliation
Polimenakos AC, Sathanandam SK, Husayni TS, El Zein CF, Roberson DA, Ilbawi MN
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Coronary Artery-to-Pulmonary Artery Fistula in a Case of Pulmonary Atresia with Ventricular Septal Defect
Sathanandam SK, Loomba RS, Ilbawi MN, Van Bergen AH
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Evaluation of Atrial and Ventricular Septal Defects with Real-time Three-Dimensional
Echocardiography: Current status and literature review
Roberson DA, Cui W
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June 2011
Three-Dimensional Transesophageal Echocardiography of Atrial Septal Defect: A Qualitative and Quantitative Anatomic Study
Roberson DA, Cui W, Patel D, Tsang W, Sugeng L, Weinert L, Bharati S, Lang RM.
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December 2010
Doppler echocardiography for managing fetal cardiac arrhythmia
Matta MJ, Cuneo BF
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November 2010
Mitral stenosis and aortic atresia in hypoplastic left heart syndrome: survival analysis after stage I palliation.
Sathanandam SK, Polimenakos AC, Roberson DA, elZein CF, Van Bergen A, Husayni TS, Ilbawi MN
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Ventriculocoronary Artery Connections With the Hypoplastic Left Heart: A 4-year Prospective Study: Incidence, Echocardiographic and Clinical Features.
Sathanandam S, Cui W, Nguyen NV, Husayni TS, Van Bergen AH, Sajan I, El-Zein C, Polimenakos A, Ilbawi MN, Roberson DA.
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September 2010
Real-Time Three-Dimensional Echocardiographic Assessment of Left Ventricular Systolic Dyssynchrony in Healthy Children.
Cui W, Gambetta K, Zimmerman F, Freter A, Sugeng L, Lang R, Roberson DA.
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Timing for successful surgical management of heart block after placement of an Amplatzer occlusion device for secundum atrial septal defect repair.
Gupta U, Al-Anani SJ, Polimenakos AC.
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Ventriculocoronary Artery Connections With the Hypoplastic Left Heart: A 4-year Prospective Study: Incidence, Echocardiographic and Clinical Features.
Sathanandam S, Cui W, Nguyen NV, Husayni TS, Van Bergen AH, Sajan I, El-Zein C, Polimenakos A, Ilbawi MN, Roberson DA.
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Selective tricuspidization and aortic cusp extension valvuloplasty: outcome analysis in infants and children.
Polimenakos AC, Sathanandam S, Blair C, Elzein C, Roberson D, Ilbawi MN.
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Hypoplastic left heart syndrome: feasibility study for patients undergoing completion fontan at or prior to two years of age.
Sathanandam S, Polimenakos AC, Blair C, El Zein C, Ilbawi MN.
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April 2010
A management strategy for fetal immune-mediated atrioventricular block
Cuneo BF, Lee M, Roberson D, Niksch A, Ovadia M, Parilla BV, Benson DW.
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Aortic cusp extension valvuloplasty with or without tricuspidization in children and adolescents: long-term results and freedom from aortic valve replacement.
Polimenakos AC, Sathanandam S, Elzein C, Barth MJ, Higgins RS, Ilbawi MN.
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March 2010
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
Sulaiman M, Matta MJ, Sunderesan NR, Gupta MP, Periasamy M, Gupta M
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November 2009
Chiari drop attacks: surgical decompression and the role of tilt table testing.
Straus D, Foster K, Zimmerman F, Frim D.
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September 2009
Novel peptide mimetic small molecules of the HAV motif in N-cadherin inhibit N-cadherin-mediated neurite outgrowth and cell adhesion
Burden-Gulley SM, Gates TJ, Craig SE, Lou SF, Oblander SA, Howell S, Gupta M, Brady-Kalnay SM.
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Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP
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July/ August 2009
Surgical repair of anomalous coronary arteries arising from the opposite sinus of Valsalva in infants and children.
elZein C, Hanhan Z, Massad M, Barth MJ, Muangmingsuk S, Geha A, Polimenakos A, Ilbawi M.
- This paper describes our surgical technique of repairing abnormal coronary arteries. The paper also reviews our surgical experience and results. It focuses on the results in infants where the timing for repair is still controversial.
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June 2009
Anesthesia and cardiopulmonary bypass for congenital heart surgery
elZein CF.
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April 2009
Tissue doppler imaging measurement of left ventricular systolic function in children: mitral annular displacement index is superior to peak velocity.
Roberson DA, Cui W
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March 2009
An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease
Cuneo BF, Strasburger JF, Niksch A, Ovadia M, Wakai RT
Approximately 1-3% of fetuses exposed to pregnant women with abnormal SSA/SSB antibodies develop an immune inflammatory disease. SSA/SSB auto-antibodies are found in the mother's blood. These auto-antibodies can cause Systemic Lupus or Sjogren's Syndrome.
Because of earlier diagnostic limitations, SSA/ SSB antibody-associated fetal cardiac disease has not been fully appreciated. With new technology such as fetal magnetocardiography (f-MCG), we are better prepared to identify new findings. Subtle changes in the fetal heart rate can now be monitored (such as first degree heart block, second degree heart block and third degree heart block) and planning and treatment can begin at much earlier stages in the pregnancy.
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February 2009
A Comparison of Tei index versus systolic to diastolic ratio to detect left ventricular dysfunction in pediatric patients
Patel DR, Cui W, Gambetta K, Roberson DA
This study analyzes the accuracy of the older Tei index versus the newer SD ratio to analyze systolic (contraction), diastolic (relaxation) or combined (both) function of the left ventricle by echocardiography (ultrasound) analysis. Both methods have an overall accuracy of > 82%, both are more accurate at detecting diastolic function and combined dysfunction than systolic dysfunction, and the older Tei Index is slightly more accurate than the newer SD ratio method. Both techniques are non-invasive, simple, useful, and best applied in combination with each other to assess left ventricular function.
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January 2009
Aortic Valvuloplasty Complications
Javois AJ
In: Hijazi ZM, Feldman T, Cheatham JP, Sievert H, eds, Complications in Percutaneous Interventions for Congenital and Structural Heart Disease, (Informa Healthcare: London, 2009).
Magnetocardiography in the assessment of fetal arrhythmia
Cuneo BF, Strasburger JF, Wakai RT
This review summarizes our 15 years of experience with magnetocardiography in the assessment and care of fetuses with abnormal heart rhythms. We include cases with both tachycardia (fast heart rate) and bradycardia (slow heart rate) and irregular rates. We also compare the accuracy and completeness of arrhythmia diagnosis by ultrasound with the diagnosis made by magneotcardiography. Finally, we discuss what will occur in the next 5 years in the field of fetal electrophysiology, which includes making magnetocardiography more available. Right now, it has only been used as a research tool in 2 institutions in the United States.
Published in Expert Review of OB/GYN 2009(4):145-153.
September 2008
Modeling the cardiac tissue electrode interface using fractional calculus.
Magin, RL and Ovadia, M
The equations that underlie electrical conduction and signal transmission for cardiac electrodes are most naturally cast in the form of differential equations not of integer order. This is because the limiting kinetic process for charge transport at the electrode|tissue interface is diffusion.
The fact that diffusion has a kinetics different from other forms of motion, can be inferred from simple examples. Say you are walking as fast as you can, at constant speed, down Broadway at 2 a.m. when there are no other people on the street. If you go a certain distance, say one block, in 1 minute, then when you have gone 3 blocks (three times the distance) you can guess that you have been walking for 3 minutes, and when you have gone 9 blocks you'll have been walking 9 minutes.
What if you're walking the same route at 2 p.m., in the massive crowds typical for that part of Manhattan at that hour. If you go a certain distance, say one block, in 1 minute, then is it true that when you have gone 3 blocks (three times the distance) you can guess that you have been walking for 3 minutes? And when you have gone 9 blocks you'll have been walking 9 minutes?
No. In the kinetics relevant to the crowded street, the fact is, that if you went one block in 1 minute, then when you have gone 3 blocks, a distance a factor-of-3 larger, then you will have been walking for 9 minutes (a time period a factor of 9=32 larger), and when you have gone 9 blocks, a distance a factor-of-9 farther, then you will have been walking for 81 minutes (81=92) minutes. This relationship of time to distance corresponds to the order of the fractional derivative, or the fractional derivative that relates the two variables-namely, 1/2.
In this contribution, we survey the field and recast equivalent circuit models for the electrode|tissue interface (which my laboratory has published over the last decade) in the form of Weyl and Riemann-Liouville fractional differential equations. This entire issue of this excellent Engineering journal is in fact devoted to mathematically similar formulations of the equations of different engineering, physical and chemical physical systems.
Magnetocardiography-guided management of an unusual case of isoimmune complete atrioventricular block complicated by ventricular tachycardia
Das B, Cuneo BF, Ovadia M, Strasburger JF, Johnsrude C, Wakai RT
About 4% of mothers who have the antibodies associated with Lupus or Sjogren's syndrome will have a fetus with an abnormally slow rhythm called heart block. Heart block often requires a pacemaker after birth. The case reported in this article is interesting because the fetus not only had heart block, but also the opposite: a faster than normal heart rate. In this case, it was a sign of fetal distress, and the baby was delivered because of it. Happily, the baby did well.
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August 2008
Treatment of fetal tachycardia
Cuneo BF
This manuscript focuses on the successful management of fetal tachycardia, an abnormal rhythm in the fetal heart that can. We summarized our 15 year experience taking care of such high risk fetuses, who all survived. This successful treatment plan is the result of combined excellence in obstetrics, neonatology and pediatric cardiology. Hopefully, this protocol will be adopted by other centers that will have the same results as ours.
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July 2008
Digoxin for the treatment of fetal congestive heart failure with sinus rhythm assessed by cardiovascular profile score
Patel D, Cuneo B, Viesca R, Rassanan J, Leshko J, Huhta J
This paper evaluated the results of treating fetuses with severe heart failure caused by leaky or narrow valves, or a primary muscle disease, with digoxin. We found that digoxin improved the outcome of these fetuses, mostly by prolonging the pregnancies so the infants could be delivered at term. This provides hope to the physicians and parents caring for the sickest fetuses.
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May 2008
Extensive left ventricular to coronary artery connections in hypoplastic left heart syndrome.
Roberson DA, Cui W, Cuneo BF, Van Bergen AH, Javois AJ, Bharati S
The echocardiographic assessment of this rare anomaly is described and illustrated as seen in the fetus and neonate before and after intervention. It is the first report to describe coronary artery interruption in this condition.
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April 2008
Systolic and diastolic time intervals measured from tissue Doppler imaging: normal values and Z score tables and effects of age, heart rate and body surface area.
Cui W, Roberson DA, Chen Z, Madronero LF, Cuneo BF
The methods of measurement and normal values for tissue Doppler imaging derived systolic and diastolic time intervals used to measure systolic and diastolic function in large group of children are presented in this report. These parameters should enhance the non-invasive capabilities to measure systolic and diastolic ventricular function in children.
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March 2008
Transcription repression and blocks in cell cycle progression in hypoplastic left heart syndrome
Gambetta K. Al-Ahdab MK. Ilbawi MN. Hassaniya N. Gupta M
Hypoplastic left heart syndrome (HLHS) is relatively a common cardiac malformation that is most therapeutically challenging. It is characterized by a marked underdevelopment of the left side of the heart, which includes the small left atrium, small or absent left ventricle (LV), stenosis or atresia of mitral valve, hypoplasia or atresia of aortic valve, and severe hypoplasia of ascending aorta. These constellations of cardiac defects severely limit the ability of the heart to send oxygen-rich blood to the body. HLHS is not compatible with life. HLHS accounts for 7.5% of all congenital heart disease diagnosed in the first year of life. Before surgical treatment became available, this malformation was universally fatal with 90% of deaths occurring in the first month of life. Despite significant advances in its surgical management, little is known about the molecular abnormalities in this syndrome.
We are the first to report here a genome-wide search examining 39,000 different human genes for the abnormally expressed genes in HLHS. Our analysis showed 288 genes to be differentially expressed. Based on their functional annotations, fundamental biological processes that are anticipated to be abnormal in HLHS are (1) blocks in cell cycle progression (2) repression in gene transcription (3) enhancement of programmed cell death and (4) disorganization of cytoskeletal structural proteins.
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Magnetocardiography in the evaluation of fetuses at risk for sudden cardiac death before birth
Cuneo BF, Strasburger JF, Wakai RT
Although most people think the greatest risk of dying is in older people, it actually is during fetal life. No one really knows why ostensibly healthy fetuses are still born after 25 weeks, but we wondered if abnormal cardiac rhythm might be one of the causes. We used a technique called magnetocardiography to obtain an electrocardiogram of the fetus with abnormal rhythm or structure. This technique is available only in a few centers throughout the world. We found that a high proportion of fetuses did have arrhythmias that were not detected by ultrasound. We next hope to study fetuses in whom family members have a rhythm problem or a history of stillbirth.
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Accelerated idioventricular rhythm in newborns: a worrisome but benign entity with or without congenital heart disease.
Freire, G, Dubrow, I
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Anomalous left coronary artery from the right sinus of Valsalva and noncompaction of the left ventricle.
Gambetta K, Cui W, el-Zein C, Roberson DA
Echocardiographic assessment is described and illustrated for this rare combination of anomalies in this report. The molecular and anatomic embryology is discussed.
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February 2008
Transcatheter closure of ruptured sinus of Valsalva aneurysm and secundum atrial septal defect with limited inferior rim.
Cui W, Van Bergen A, Patel D, Javois AJ, Roberson DA
Echocardiographic assessment and guidance of interventional therapies for this rare combination of anomalies is described and illustrated in this report.
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January 2008
Double aortic arch and D-transposition of the great arteries.
Cui W, Patel D, Husayni TS, Roberson DA
This article describes and illustrates with echocardiograms and 3D CT scans the rare association of double aortic arch with transposition of the great arteries. Echocardiographic features and techniques to prospectively make the diagnosis are described.
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Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression
Pillai JB, Chen M, Rajamohan SB, Samant S, Pillai VB, Gupta M, Gupta MP
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Electrophysiological characteristics of fetal atrioventricular block
Zhao H, Cuneo BF, Strasburger JF, Huhta JC, Gotteiner NL, Wakai RT.
Magnetocardiography, which is a non-invasive test and presents no danger to mother or fetus, has also guided the management of unusual life threatening arrhythmias and diagnosed unsuspected and never before seen malignant arrhythmias in families with a genetic predisposition to abnormal rhythms. We used magneotcardiography to study a large group of fetuses with heart block: an abnormal rhythm that often requires a pacemaker. The fMCG helped us predict which fetus required pacemakers immediately after birth. We found unsuspected arrhythmias along with AVB, in 25-75% of fetuses.
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