Renal papillary necrosis is a disorder of the kidneys in which all or part of the renal papillae die. The renal papillae are the areas where the openings of the collecting ducts enter the kidney, and where the urine flows into the ureters.
How well a person does depends on what is causing the condition. If the cause can be controlled, the condition may go away on its own. In some cases, persons with this condition develop kidney failure and will need dialysis or a kidney transplant.
There is no specific treatment for renal papillary necrosis. Treatment depends on the cause. For example, if analgesic nephropathy is the cause, your doctor will recommend that you stop using the medicine that is causing it. This may allow the kidney to heal over time.
You develop other symptoms of renal papillary necrosis, especially after taking over-the-counter pain medications
Controlling diabetes or sickle cell anemia may reduce your risk. To prevent renal papillary necrosis from analgesic nephropathy, be careful when using medications, including over-the-counter pain relievers.
Kanso AA, Abou Hassan NM, Badr KF. Microvascular and macrovascular diseases of the kidney. In: Brenner BM, ed. Brenner and Rector's the Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 32.
Porter CC, Ayner Ed. Hematologic diseases causing hematuria. In: Kliegman RM, Stanton BF, St. Geme JW III. Schor NF, Behrman RE, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 514.
Charles Silberberg, DO, Private Practice specializing in Nephrology, Affiliated with New York Medical College, Division of Nephrology, Valhalla, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.