Clinical Research

Advanced Disease:

Phase II study of high dose doxorubicin + high dose ifosfamide with autologous whole-blood- derived peripheral stem cell support for advanced sarcomas.

Phase II study of toremifene for recurrent or unresectable desmoid tumors

Bone Marrow Transplant Studies
Phase II study of positive stem cell selection prior to high dose chemotherapy with autologous stem cell rescue (bone marrow transplant.)

Induction chemotherapy followed by tandem (two) high dose chemotherapies with autologous stem cell rescue (bone marrow transplants.)

Induction chemotherapy followed by high dose chemotherapy (STAMP-V) with autologous stem cell rescue (bone marrow transplant) using interleukin-2 immune stimulation pre- and post-transplant.

Breast Cancer
Prevention:
Breast Cancer Prevention Trial - tamoxifen for prevention of breast cancer.

Adjuvant therapy:
[0 - 3 lymph nodes + ] - concurrent v sequential doxorubicin + cyclophosphamide.

[lymph node +] - fixed dose cyclophosphamide, one of three dose levels of doxorubicin, each with or without subsequent Taxol chemotherapy.

[lymph node + >

4 nodes] induction chemotherapy followed by high dose chemotherapy with autologous stem cell rescue (bone marrow transplant).

Evaluation of weight loss in patients who have completed adjuvant chemotherapy for breast cancer (one year Weight Watchers program provided free of charge.)

Metastatic breast cancer:
Phase II study of ifosfamide and Navelbine.

Phase III study of chemotherapy with or without anti-Her2 antibody.

Phase II study of anti-Her2 antibody.

Phase III study of Taxol with or without mitoxantrone.

Phase III study of doxorubicin + cyclophosphamide v losoxantrone + cyclophosphamide.

Phase II study of positive stem cell selection prior to high dose chemotherapy with autologous stem cell rescue (bone marrow transplant.)

Induction chemotherapy followed by tandem (two) high dose chemotherapies with autologous stem cell rescue (bone marrow transplants.)

Induction chemotherapy followed by high dose chemotherapy (STAMP-V) with autologous stem cell rescue (bone marrow transplant) using interleukin-2 immune stimulation pre- and post-transplant.

Colon Cancer
Adjuvant:
Phase III study of 5-Fluorouracil and levamisole with and without Panorex (17-1A antibody) for patients with surgically resected, locally advanced (Dukes' C) colon cancer.

Advanced Disease:
Phase III randomized study of sequential trimetrexate and 5-fluorouracil + leucovorin vs 5-fluorouracil + leucovorin for advanced colorectal cancer.

[Prior therapy] Phase II study of sequential trimetrexate and 5-fluorouracil + leucovorin for advanced colorectal cancer.

Colorectal Cancer
Prevention:
Colorectal Adenoma Prevention Study—use of aspirin to prevent regrowth of new polyps after treatment for colorectal cancer.

Gastric (Stomach) Cancer
Advanced Disease:
Phase II study of BR-96-Doxorubicin immunoconjugate for advanced upper gastrointestinal malignancies

Lung Cancer
Prevention:
13 cis-Retinoic acid for prevention of second primary lung cancers.

Small Cell Lung Cancer
Limited stage (confined to chest):
Phase III study of cisplatin + etoposide with thoracic radiation therapy with or without tamoxifen therapy.

Advanced Disease:
Phase II study of Taxol + doxorubicin.

Non-Small Cell Lung Cancer
Locally Advanced Disease:
Phase III study of sequential chemotherapy (cisplatin + etoposide) and radiation v concurrent chemotherapy (cisplatin + etoposide or cisplatin and oral etoposide) and radiation.

Advanced Disease:
Phase II study of 9-aminocamptothecin.

Phase II study of Taxol, ifosfamide, and Navelbine.

Lymphoma
Advanced Low Grade:
Phase II study of 2-chlorodeoxyadenosine + interferon-alpha.

Refractory Disease:
Phase II study of I131-Lym-1 radio-immunotherapy for refractory lymphoma.

Post transplant:
Phase III randomized study of adjuvant therapy with anti-B4-blocked-ricin immunotoxin therapy vs observation.

Phase II study of salvage therapy with donor lymphocyte infusion in patients who have relapsed after allogeneic transplant.

Phase II study of positive stem cell selection prior to high dose chemotherapy with autologous stem cell rescue (bone marrow transplant.)

Phase II study of high dose chemotherapy (cyclophosphamide + etoposide) and total body irradiation with autologous stem cell rescue (bone marrow transplant. )

Induction chemotherapy followed by high dose chemotherapy (STAMP-V) with autologous stem cell rescue (bone marrow transplant) using interleukin-2 immune stimulation pre- and post-transplant.

Melanoma
Adjuvant Therapy:
Phase III study of postoperative interferon-alpha with or without melacine vaccine.

Advanced Disease:
Phase III study of daily injection vs continuous subcutaneous infusion of interleukine-2 following chemo-immunotherapy.

Phase II study of paclitaxel + cisplatin followed by chemo-immunotherapy with interleukine-2 and interferon-alfa.

Prevention Studies
Breast Cancer Prevention Trial - tamoxifen for prevention of breast cancer.

Colorectal Adenoma Prevention Study - use of aspirin to prevent regrowth of new polyps after treatment for colorectal cancer.

13 cis-Retinoic acid for prevention of second primary lung cancers.

Lymphoma - Post transplant:
Phase III randomized study of adjuvant therapy with anti-B4-blocked-ricin immunotoxin therapy vs observation.

Phase II study of salvage therapy with donor lymphocyte infusion in patients who have relapsed after allogeneic transplant.

Phase II study of positive stem cell selection prior to high dose chemotherapy with autologous stem cell rescue (bone marrow transplant.)

Phase II study of high dose chemotherapy (cyclophosphamide + etoposide) and total body irradiation with autologous stem cell rescue (bone marrow transplant.)

Induction chemotherapy followed by high dose chemotherapy (STAMP-V) with autologous stem cell rescue (bone marrow transplant) using interleukin-2 immune stimulation pre- and post-transplant.

Prostate Cancer
Locally Advanced Disease:
Phase III study of radiation therapy with and without induction therapy with total androgen blockade hormone therapy.

Advanced Disease:
Phase II study of suramin for advanced, hormone-refractory prostate cancer.

Phase II study of oral trimethyl-colchicinic acid for advanced, hormone-refractory prostate cancer.

Rectal Cancer
Neoadjuvant:
Phase II study of preoperative concurrent chemotherapy (Mitomycin C + 5-Fluorouracil) and radiation therapy for cancer of the rectum.

Cancer Care Center
Clinical Research Studies